N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

Base Information

Chemical Name:N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide
CAS No.:85370-84-9
Molecular Formula:C₂₅H₄₃N₃O₄Si
Molecular Weight:477.72
Hs Code.:

Synonyms:N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

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Chemical Property of N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

Chemical Property:

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Technology Process of N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

There total 4 articles about N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85370-85-0
N,N-diethyl-3-methoxy-2-(trimethylsilyl)benzamide

: 85370-84-9
N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h

2: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
DOI:10.1021/jo00279a028

Reference yield:

: 85370-78-1
N,N-diethyl-2-(diethylcarbamoyl)-4-methoxy-3-(trimethylsilyl)benzamide

: 88-10-8
N,N-diethylcarbamyl chloride

: 85370-84-9
N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

Guidance literature:: With sec.-butyllithium; Yield given. Multistep reaction; 1.) TMEDA, THF, -78 deg C;
DOI:10.1021/jo00157a047

Reference yield:

: 62924-93-0
N,N-diethyl-3-methoxybenzamide

: 85370-84-9
N,N-diethyl-2,3-bis(diethylcarbamoyl)-5-methoxy-6-(trimethylsilyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h

2: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h

3: 1.) s-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) THF, cyclohexane, from -78 deg C to RT, 8 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
DOI:10.1021/jo00279a028