Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate
3.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
4.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere
5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
6.1: water; lithium hydroxide / 1,4-dioxane / 16 h / 35 °C
With
water; hydrogen; potassium acetate; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium hydroxide;
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; mineral oil;