2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

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Chemical Name:2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid
CAS No.:1402465-18-2
Molecular Formula:C₂₇H₃₀ClN₃O₄
Molecular Weight:496.006
Hs Code.:

Synonyms:2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

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Chemical Property of 2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

There total 7 articles about 2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402466-04-9
methyl 2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetate

: 1402465-18-2
2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: methyl 2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetate; With water; lithium hydroxide; In 1,4-dioxane; at 35 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 13524-04-4,131864-71-6,132437-66-2,120466-66-2
(R)-1-(o-chlorophenyl)ethanol

: 1402465-18-2
2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane; toluene / 1 h / 0 - 20 °C / Molecular sieve 4?; Inert atmosphere; Reflux

1.2: 20 °C / Reflux

2.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

3.1: water; lithium hydroxide / 1,4-dioxane / 16 h / 35 °C

With pyridine; water; sodium hydrogencarbonate; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 105640-07-1
4-(4-hydroxyphenyl)cyclohexan-1-one

: 1402465-18-2
2-((1r,4r)-4-(4-(5-(((R)-1-(2-chlorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl)phenyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

3.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

6.1: water; lithium hydroxide / 1,4-dioxane / 16 h / 35 °C

With water; hydrogen; potassium acetate; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; mineral oil;