benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

Base Information

Chemical Name:benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate
CAS No.:1314531-84-4
Molecular Formula:C₂₉H₃₃N₃O₄
Molecular Weight:487.599
Hs Code.:

Synonyms:benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

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Chemical Property of benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

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Technology Process of benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

There total 6 articles about benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1314531-75-3
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenylpropionic acid

: 3-methyl-1-vinyl-butylamine

: 1314531-84-4
benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 100 ℃; for 2h; Microwave irradiation;
DOI:10.1002/cmdc.201100093

Reference yield:

: 1056475-51-4
(S)-2-(3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-3-phenylpropionic acid methyl ester

: 1314531-84-4
benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093

Reference yield:

: 13673-95-5
(S)-methyl 2-hydroxy-3-phenylpropanoate

: 1314531-84-4
benzyl-1-((S)-1-((S)-5-methylhex-1-en-3-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100093