7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

Base Information

Chemical Name:7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide
CAS No.:1333214-33-7
Molecular Formula:C₂₅H₂₄ClFN₆O₃S
Molecular Weight:543.021
Hs Code.:

Synonyms:7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

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Chemical Property of 7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

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Technology Process of 7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

There total 1 articles about 7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1333214-33-7
7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃;

Reference yield: 12.0%

: 590-28-3
potassium cyanate

: 1333214-33-7
7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

: 1426249-65-1
N-carbamoyl-7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidin-1-carbonyl]pyrazolo[1,5-a]pyrimidin-3-sulfonamide

Guidance literature:: potassium cyanate; 7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide; In 1,4-dioxane; at 80 ℃; for 48h;

With water; In 1,4-dioxane;

Reference yield: 11.0%

: 1333214-33-7
7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

: 107873-03-0,1883301-82-3,1631747-25-5
2,2-difluorocyclopropane-1-carboxylic acid

: 1333213-87-8
7-(2-chloro-5-methylphenylamine)-N-(2,2-difluorocyclopropylcarbamoyl)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide

Guidance literature:: 2,2-difluorocyclopropane-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; for 2h; Reflux;

7-(2-chloro-5-methylphenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]pyrazolo[1,5-a]pyrimidine-3-sulfonamide; With potassium carbonate; In 1,4-dioxane; at 50 ℃; for 3h;