4-Phenyl-2-imidazolidinone

Base Information

• Chemical Name: 4-Phenyl-2-imidazolidinone
• CAS No.: 27129-49-3
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.191
• Mol file: 27129-49-3.mol

Synonyms:NSC 280722;4-phenylimidazolidin-2-one;

Chemical Property of 4-Phenyl-2-imidazolidinone

Chemical Property:

• Vapor Pressure: 3.59E-07mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 200.4 °C
• PSA: 41.13000
• Density: 1.146 g/cm³
• LogP: 1.69810
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Phenyl-2-imidazolidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Phenyl-2-imidazolidinone is a metabolite of Levamisole (L331100) as well as a related compound of Aminorex (A629200).

Technology Process of 4-Phenyl-2-imidazolidinone

There total 18 articles about 4-Phenyl-2-imidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C16H16N2O3 → 4-phenylimidazolidin-2-one (27129-49-3)

Guidance literature:

With 1,10-Phenanthroline; iron(II) chloride tetrahydrate; sodium carbonate; In acetonitrile; at 50 ℃; for 14h; Schlenk technique;

DOI:10.1002/anie.202013687

Reference yield: 69.0%

5-phenylimidazolidine-2,4-dione (89-24-7,27534-86-7) → 4-phenylimidazolidin-2-one (27129-49-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 72h; Heating;

DOI:10.1021/jo00161a021

Reference yield: 49.0%

2-phenylsuccinic anhydride (1131-15-3,112489-85-7) → 4-phenylimidazolidin-2-one (27129-49-3)

Guidance literature:

With trimethylsilylazide; In tetrahydrofuran; for 30h; Reflux;

DOI:10.1016/j.mencom.2016.01.027

upstream raw materials:

(S)-3-benzoylamino-3-phenyl-propionic acid amide

ethyl (3S)-3-amino-3-phenylpropionate

ethyl (S)-3-benzamido-3-phenylpropionate

4-phenyl-1,3-dihydro-imidazol-2-one

Downstream raw materials:

5-phenyl-3H-[1,3,4]oxadiazol-2-one

1-methyl-4-phenylimidazolidin-2-one

1,2-diaminophenylethane

1-(7-(4-methylpiperazin-1-yl)furo[2,3-c]pyridin-5-yl)-3-phenylimidazolidin-2-one