2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

Base Information

• Chemical Name: 2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate
• CAS No.: 1148012-80-9
• Molecular Formula: C₃₃H₃₆ClN₅O₈
• Molecular Weight: 666.131

Synonyms:2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

Chemical Property of 2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

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Technology Process of 2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

There total 1 articles about 2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.5%

2-(4-aminopiperidin-1-yl)ethyl 4 amino-5-chloro-2-methoxybenzoate hydrochloride (1148012-79-6) + 6-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid (172227-57-5) → 2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate (1148012-80-9)

Guidance literature:

6-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333 - 0.166667h;

2-(4-aminopiperidin-1-yl)ethyl 4 amino-5-chloro-2-methoxybenzoate hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 20h;

DOI:10.1021/jm801327q

Reference yield: 91.0%

2-[4-({6-[6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate (1148012-80-9) → 2-[4-({6-[6-amino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate (1148012-81-0)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 14h; under 760.051 Torr;

DOI:10.1021/jm801327q

upstream raw materials:

2-(4-aminopiperidin-1-yl)ethyl 4 amino-5-chloro-2-methoxybenzoate hydrochloride

6-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid

Downstream raw materials:

2-[4-({6-[6-amino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

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