{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

Base Information

Chemical Name:{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester
CAS No.:1027905-12-9
Molecular Formula:C₂₃H₂₃NO₄
Molecular Weight:377.44
Hs Code.:

Synonyms:{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

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Chemical Property of {3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

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Technology Process of {3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

There total 10 articles about {3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61227-57-4
7-methoxy-2-methylindan-1-one

: 1027905-12-9
{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

2: 23 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 6 h / 50 °C

3: 59 percent / H₂, AcOH / PtO₂

4: 59 percent / NaOMe / methanol / 2.67 h / Heating

5: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

6: BBr₃ / CH₂Cl₂

7: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF from 0 deg C to RT

With ammonium hydroxide; N-Bromosuccinimide; Perbenzoic acid; hydrogen; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane;
DOI:10.1021/jm960395q

Reference yield:

: 61227-51-8
3-(3-methoxyphenyl)-2-methylpropionic acid

: 1027905-12-9
{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 17 percent / polyphosphoric acid / 2 h / 90 °C

2: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

3: 23 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 6 h / 50 °C

4: 59 percent / H₂, AcOH / PtO₂

5: 59 percent / NaOMe / methanol / 2.67 h / Heating

6: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

7: BBr₃ / CH₂Cl₂

8: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF from 0 deg C to RT

With ammonium hydroxide; N-Bromosuccinimide; Perbenzoic acid; PPA; hydrogen; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane;
DOI:10.1021/jm960395q

Reference yield:

: 66735-17-9
3-(3-methoxyphenyl)-2-methylacrylic acid

: 1027905-12-9
{3-Carbamoylmethyl-2-methyl-1-[1-phenyl-meth-(E)-ylidene]-1H-inden-4-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / H₂ / 10percent Pd/C / methanol / 2280 Torr

2: 17 percent / polyphosphoric acid / 2 h / 90 °C

3: 1.) NaH / 1.) toluene, 0 deg C, 1 h, 2.) toluene, reflux, 4 h

4: 23 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 6 h / 50 °C

5: 59 percent / H₂, AcOH / PtO₂

6: 59 percent / NaOMe / methanol / 2.67 h / Heating

7: 1.) Et₃N, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 2.) aq. NH₄OH / 1.) CH₃CN, RT, 45 min, 2.) CH₃CN, RT, 30 min

8: BBr₃ / CH₂Cl₂

9: 1.) NaH / 1.) DMF, RT, 60 min, 2.) DMF from 0 deg C to RT

With ammonium hydroxide; N-Bromosuccinimide; Perbenzoic acid; PPA; hydrogen; sodium methylate; boron tribromide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane;
DOI:10.1021/jm960395q