2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Base Information

Chemical Name:2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine
CAS No.:1610966-26-1
Molecular Formula:C₁₉H₁₇FN₆O
Molecular Weight:364.382
Hs Code.:

Synonyms:2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

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Chemical Property of 2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

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Technology Process of 2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

There total 5 articles about 2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610966-61-4
6-chloro-2-(6-fluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-methoxyphenyl)pyrimidin-4-amine

: 1610966-26-1
2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: With ammonium hydroxide; In dimethyl sulfoxide; at 170 ℃; for 1h; Microwave irradiation; Sealed tube;

Reference yield:

: 1610966-58-9
4,6-dichloro-N-(5-fluoro-2-nitrophenyl)pyrimidin-2-amine

: 1610966-26-1
2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

2: acetic acid / acetonitrile / 18 h / 20 °C

3: acetonitrile / 18 h / 80 °C

4: ammonium hydroxide / dimethyl sulfoxide / 1 h / 170 °C / Microwave irradiation; Sealed tube

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; acetic acid; In dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

: 1610966-59-0
N¹-(4,6-dichloropyrimidin-2-yl)-5-fluorobenzene-1,2-diamine

: 1610966-26-1
2-(6-fluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-methoxyphenyl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / acetonitrile / 18 h / 20 °C

2: acetonitrile / 18 h / 80 °C

3: ammonium hydroxide / dimethyl sulfoxide / 1 h / 170 °C / Microwave irradiation; Sealed tube

With ammonium hydroxide; acetic acid; In dimethyl sulfoxide; acetonitrile;