(N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester

Base Information

• Chemical Name: (N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester
• CAS No.: 212143-40-3
• Molecular Formula: C₁₅H₁₅N₃O₅
• Molecular Weight: 317.301
• Mol file: 212143-40-3.mol

Synonyms:(N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester

Chemical Property of (N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester

There total 4 articles about (N⁴-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

benzyl chloroformate (501-53-1,94274-21-2) + methyl (cytosine-1-yl)acetate (186046-91-3) → (N4-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester (212143-40-3)

Guidance literature:

With dmap; In dichloromethane; at -15 - 20 ℃; for 5.25h;

DOI:10.1016/S0040-4020(02)00527-6

Reference yield:

bromoacetic acid methyl ester (96-32-2) + N-benzyloxycarbonyl cytosine (149411-91-6) → (N4-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester (212143-40-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/ja00050a068

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (N4-(benzyloxycarbonyl)cytosin-1-yl)acetic acid methyl ester (212143-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0 °C

2: K₂CO₃ / dimethylformamide / Ambient temperature

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ja00050a068

upstream raw materials:

bromoacetic acid methyl ester

N-benzyloxycarbonyl cytosine

benzyl chloroformate

methyl (cytosine-1-yl)acetate