1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Base Information

Chemical Name:1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride
CAS No.:1402465-72-8
Molecular Formula:C₂₉H₂₈N₄O₅*ClH
Molecular Weight:552.994
Hs Code.:

1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Synonyms:1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Suppliers and Price of 1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

There total 7 articles about 1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402466-28-7
1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid

: 1402465-72-8
1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Guidance literature:: 1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid; With water; lithium hydroxide; In d⁽⁴⁾-methanol; at 20 ℃; for 168h;

With hydrogenchloride; In water;

Reference yield:

: 39891-09-3
(6-chloro-pyridin-3-yl)-acetonitrile

: 1402465-72-8
1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-Bromo-2-chloroethane; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 5 h / 50 °C

1.2: 100 °C

2.1: sulfuric acid / Reflux

3.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 120 h / 20 °C

5.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; 1,4-dioxane / 144 h / 120 °C

6.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

7.1: water; lithium hydroxide / d⁽⁴⁾-methanol / 168 h / 20 °C

With pyridine; potassium phosphate; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; water; 1-Bromo-2-chloroethane; triethylamine; sodium hydroxide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; d⁽⁴⁾-methanol; water;

Reference yield:

: 854267-90-6
1-(6-chloropyridin-3-yl)cyclopropanecarboxylic acid

: 1402465-72-8
1-(6-{3-methoxy-4-[1-methyl-5-(1,2,2,2-tetradeutro-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-phenyl}-pyridin-3-yl)-cyclopropanecarboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / Reflux

2: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere

3: pyridine / dichloromethane / 120 h / 20 °C

4: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; 1,4-dioxane / 144 h / 120 °C

5: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

6: water; lithium hydroxide / d⁽⁴⁾-methanol / 168 h / 20 °C

With pyridine; potassium phosphate; sulfuric acid; water; triethylamine; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; d⁽⁴⁾-methanol; water;