methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate

Base Information

• Chemical Name: methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate
• CAS No.: 634206-64-7
• Molecular Formula: C₃₂H₄₃N₂O₉PSi
• Molecular Weight: 658.761

Synonyms:methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate

Chemical Property of methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate

There total 3 articles about methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

[[3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-(tetrahydro-pyran-2-yloxy)-methyl]-phosphonic acid dimethyl ester → methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate (634206-64-7)

Guidance literature:

With pyridine; In water; at 50 ℃; for 48h;

DOI:10.1081/NCN-120021432

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate (634206-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium 4-toluenesulfonate / CH₂Cl₂ / 96 h / 20 °C

2: 67 percent / pyridine / H₂O / 48 h / 50 °C

With pyridine; pyridinium p-toluenesulfonate; In dichloromethane; water;

DOI:10.1081/NCN-120021432

Reference yield:

dimethyl 3'-O-tert-butyldiphenylsilylthymidin-5'-C-ylphosphonate → methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate (634206-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium 4-toluenesulfonate / CH₂Cl₂ / 96 h / 20 °C

2: 67 percent / pyridine / H₂O / 48 h / 50 °C

With pyridine; pyridinium p-toluenesulfonate; In dichloromethane; water;

DOI:10.1081/NCN-120021432

upstream raw materials:

3,4-dihydro-2H-pyran

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 634206-64-7 methyl 3'-O-tert-butyldiphenylsilyl-2'-deoxythymidinyl-5'-O-(tetrahydropyran-2-yl)-5'-C-phosphonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send