(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

Base Information

Chemical Name:(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine
CAS No.:1375800-72-8
Molecular Formula:C₁₈H₂₇FN₂O
Molecular Weight:306.424
Hs Code.:

Synonyms:(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

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Chemical Property of (E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

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Technology Process of (E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

There total 3 articles about (E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₅FN₂O

: 1375800-72-8
(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

Guidance literature:: C₁₈H₂₅FN₂O; With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

With acetone; In methanol; at 20 ℃; for 0.166667h;

With water; potassium carbonate; In dichloromethane; pH=> 10;
DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

: 1375800-41-1
(E)-3-(2-fluoro-4-methoxyphenyl)-2-methylacrylaldehyde

: 1375800-72-8
(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / dichloromethane / 96 h / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

2.3: pH > 10

With sodium tetrahydroborate; magnesium sulfate; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

: 331-64-6
2-fluoro-4-methoxy-benzaldehyde

: 1375800-72-8
(E)-3-(2-fluoro-4-methoxyphenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 96 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 20 °C

3.3: pH > 10

With sodium tetrahydroborate; magnesium sulfate; potassium hydroxide; In methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.02.041