α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

Base Information

Chemical Name:α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide
CAS No.:137650-60-3
Molecular Formula:C₂₇H₄₀N₂O₄
Molecular Weight:456.626
Hs Code.:

Synonyms:α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

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Chemical Property of α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

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Technology Process of α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

There total 8 articles about α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-1-[(S)-2-tert-Butoxy-1-(3-phenyl-propoxymethyl)-ethylcarbamoyl]-2-(4-hydroxy-2,6-dimethyl-phenyl)-ethyl]-carbamic acid benzyl ester

: 137650-60-3
α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 258.6 Torr;
DOI:10.1021/jm00080a005

Reference yield:

: 69804-99-5
3-phenylpropanol methanesulfonate

: 137650-60-3
α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, a.) RT, 1 h, b.) 50 deg C, 2 h, 2.) THF, a.) 40 deg C, 16 h, b.) reflux, 2 h

2: 58 percent / 6N aq. H₂SO₄ / 16 h / Heating

3: 48 percent / conc. H₂SO₄ / CH₂Cl₂ / 16 h

4: 4-methylmorpholine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

5: H₂ / 10percent Pd/C / ethanol / 258.6 Torr

With 4-methyl-morpholine; sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 123715-02-6
H-Dmt

: 137650-60-3
α(S)-amino-N-<1(S)-<(1,1-dimethylethoxy)methyl>-2-(3-phenylpropoxy)ethyl>-4-hydroxy-2,6-dimethylbenzenepropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / 12.5percent aq. NaOH / 16 h

2: 4-methylmorpholine / tetrahydrofuran / 0.75 h / -23 °C

3: 4-methylmorpholine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: H₂ / 10percent Pd/C / ethanol / 258.6 Torr

With 4-methyl-morpholine; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00080a005