(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

Base Information

Chemical Name:(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid
CAS No.:150544-89-1
Molecular Formula:C₂₁H₃₁NO₆S
Molecular Weight:425.546
Hs Code.:

Synonyms:(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

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Chemical Property of (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

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Technology Process of (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

There total 5 articles about (2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.6%

: 150544-88-0
(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>thio>propionic acid

: 150544-89-1
(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

Guidance literature:: With Oxone; In methanol; water; for 40h; Ambient temperature;
DOI:10.1021/jm00071a009

Reference yield:

: 20593-63-9
2-Benzylacrylic acid ethyl ester

: 150544-89-1
(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium hexamethyldisilylamide / 1.) methanol, RT, 1 h, 2.) methanol, RT, 1 h

2: 100 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h

3: 51.6 percent / oxone / methanol; H₂O / 40 h / Ambient temperature

With Oxone; sodium hydroxide; sodium hexamethyldisilazane; In methanol; 1,2-dimethoxyethane; water;
DOI:10.1021/jm00071a009

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 150544-89-1
(2RS)-2-benzyl-3-<<4-<(tert-butyloxycarbonyl)amino>cyclohexyl>sulfonyl>propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 29.8 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 15 h / -60 - 20 °C

2: 1.) sodium hexamethyldisilylamide / 1.) methanol, RT, 1 h, 2.) methanol, RT, 1 h

3: 100 percent / aq. NaOH / 1,2-dimethoxy-ethane / 48 h

4: 51.6 percent / oxone / methanol; H₂O / 40 h / Ambient temperature

With Oxone; sodium hydroxide; sodium hexamethyldisilazane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;
DOI:10.1021/jm00071a009