N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

Base Information

Chemical Name:N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide
CAS No.:1456620-77-1
Molecular Formula:C₂₂H₂₅N₅O₂
Molecular Weight:391.473
Hs Code.:

Synonyms:N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

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Technology Process of N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

There total 3 articles about N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 204973-87-5
[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

: 1456620-77-1
N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

Guidance literature:: With sulfuric acid; In ethanol; for 2h; Reflux;
DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1456620-77-1
N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2: hydrazine hydrate / ethanol / 9 h / Reflux

3: sulfuric acid / ethanol / 2 h / Reflux

With sulfuric acid; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

: 63854-11-5
ethyl [4-(2-methoxyphenyl)piperazin-1-yl]acetate

: 1456620-77-1
N'-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 9 h / Reflux

2: sulfuric acid / ethanol / 2 h / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2013.06.045