N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide

Base Information

• Chemical Name: N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide
• CAS No.: 916052-28-3
• Molecular Formula: C₁₄H₁₃Cl₂N₃O₂S
• Molecular Weight: 358.248
• Mol file: 916052-28-3.mol

Synonyms:N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide

Chemical Property of N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide

There total 2 articles about N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-1,5-dinitrobenzene (3698-83-7) → N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide (916052-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / Raney_.(R). nickel / methanol / 18 h / 760.05 Torr

2.1: ethanol / 5 h / Heating / reflux

3.1: pyridine / 18 h

3.2: 0.5 h

3.3: Acidic conditions

With pyridine; hydrogen; Raney nickel; In methanol; ethanol;

Reference yield:

4,6-dichloro-1,3-benzenediamine (20248-64-0) → N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide (916052-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 5 h / Heating / reflux

2.1: pyridine / 18 h

2.2: 0.5 h

2.3: Acidic conditions

With pyridine; In ethanol;

Reference yield: 73.0%

quinoline-6-carbaldehyde (4113-04-6) + N-{2,4-dichloro-5-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}cyclobutanecarboxamide (916052-28-3) → N-(2,4-dichloro-5-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide (916052-26-1)

Guidance literature:

With piperdinium acetate; In ethanol; at 150 ℃; for 0.5h; Microwave heating;

upstream raw materials:

2,4-dichloro-1,5-dinitrobenzene

4,6-dichloro-1,3-benzenediamine

Downstream raw materials:

N-(2,4-dichloro-5-{[(5Z)-4-oxo-5-(6-quinolinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide