7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:1235484-29-3
Molecular Formula:C₂₄H₃₁ClN₂O
Molecular Weight:398.976
Hs Code.:

Synonyms:7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of 7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 6 articles about 7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1235484-29-3
7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: tert-butyl 7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate; With trifluoroacetic acid; at 20 ℃; for 16h;

With sodium hydroxide; In water; ethyl acetate;
DOI:10.1016/j.bmc.2011.09.007

Reference yield:

: 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

: 1235484-29-3
7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 18 h / 20 - 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3: potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide / N,N-dimethyl-formamide / 16 h / 60 °C

4: trifluoroacetic acid / 16 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.007

Reference yield:

: 684250-23-5
tert-butyl 7-(3-chloropropoxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1235484-29-3
7-{3-[4-(4-chlorophenyl)piperidin-1-yl]propoxy}-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide / N,N-dimethyl-formamide / 16 h / 60 °C

2: trifluoroacetic acid / 16 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.09.007