N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide
CAS No.:1226894-90-1
Molecular Formula:C₂₈H₃₄F₃N₅O₃
Molecular Weight:545.605
Hs Code.:

Synonyms:N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

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Chemical Property of N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

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Technology Process of N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

There total 6 articles about N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1261061-75-9
N-{[1-(2-hydroxypropyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

: 13754-38-6
N-Benzoylpiperazine

: 1226894-90-1
N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: N-{[1-(2-hydroxypropyl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 3 ℃; for 0.5h; Inert atmosphere;

N-Benzoylpiperazine; With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: N-[(1-benzylpyrrolidine-(3R)-yl-carbamoyl)-methyl]-3-trifluoromethylbenzamide

: 1226894-90-1
N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

2.1: calcium carbonate / acetonitrile / 20 °C / Reflux

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 3 °C / Inert atmosphere

3.2: 2 h / 20 °C

With methanesulfonyl chloride; triethylamine; calcium carbonate; palladium(II) hydroxide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 17794-48-8
m-trifluoromethylhippuric acid

: 1226894-90-1
N-{[1-(2-(4-benzoylpiperazine-1-yl)propane-1-yl)-pyrrolidine-(3R)-yl-carbamoyl]-methyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -10 °C / Inert atmosphere

1.2: 1 h / -10 °C / Inert atmosphere

2.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C / 760.05 Torr

3.1: calcium carbonate / acetonitrile / Reflux

4.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 3 °C / Inert atmosphere

4.2: 2 h / 20 °C

With 4-methyl-morpholine; hydrogen; methanesulfonyl chloride; triethylamine; calcium carbonate; isobutyl chloroformate; palladium(II) hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;