C₂₈H₃₁N₅OSi

Base Information

Chemical Name:C₂₈H₃₁N₅OSi
CAS No.:1188474-82-9
Molecular Formula:C₂₈H₃₁N₅OSi
Molecular Weight:481.673
Hs Code.:

C<sub>28</sub>H<sub>31</sub>N<sub>5</sub>OSi

Synonyms:C₂₈H₃₁N₅OSi

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₈H₃₁N₅OSi

Chemical Property:

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Technology Process of C₂₈H₃₁N₅OSi

There total 10 articles about C₂₈H₃₁N₅OSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188474-81-8
9-[(1S,2S,5R)-5-(tert-butyl-diphenylsilanyloxymethyl)bicyclo[3.1.0]hex-3-en-2-yl]-6-chloro-9H-purine

: 1188474-82-9
C₂₈H₃₁N₅OSi

Guidance literature:: With ammonia; In methanol; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.05.026

Reference yield:

: (1R,5S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-oxa-bicyclo[3.1.0]hexan-2-one

: 1188474-82-9
C₂₈H₃₁N₅OSi

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7.1: ammonia / methanol / 4 h / 80 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; oxalyl dichloride; potassium tert-butylate; ammonia; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; dichloromethane; 2.2: Wittig reaction / 3.1: Swern oxidation / 3.2: Swern oxidation / 4.1: Grignard reaction / 4.2: Grignard reaction / 6.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.05.026

Reference yield:

: (+)-(1R,5S)-1-(hydroxymethyl)-3-oxabicyclo[3.1.0]hexan-2-one

: 1188474-82-9
C₂₈H₃₁N₅OSi

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

8.1: ammonia / methanol / 4 h / 80 °C / Inert atmosphere

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; oxalyl dichloride; potassium tert-butylate; ammonia; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; hexane; dichloromethane; 3.2: Wittig reaction / 4.1: Swern oxidation / 4.2: Swern oxidation / 5.1: Grignard reaction / 5.2: Grignard reaction / 7.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.05.026