(+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine

Base Information

• Chemical Name: (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine
• CAS No.: 137655-95-9
• Molecular Formula: C₁₆H₁₇N₅O₃
• Molecular Weight: 327.343

Synonyms:(+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine

Chemical Property of (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine

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Technology Process of (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine

There total 4 articles about (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

solketal tosylate (23737-51-1,7305-59-1) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-95-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 38 percent / NaN₃ / dimethylformamide / 12 h / 60 °C

2: Na, EtOH / Heating

3: 3 h / Heating

With sodium azide; ethanol; sodium; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570280529

Reference yield:

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol (100-79-8,36543-79-0) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-95-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / pyridine

2: 38 percent / NaN₃ / dimethylformamide / 12 h / 60 °C

3: Na, EtOH / Heating

4: 3 h / Heating

With pyridine; sodium azide; ethanol; sodium; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570280529

Reference yield:

4-(azidomethyl)-2,2?dimethyl-1,3-dioxolane (25261-56-7) → (+/-)-3-2',3'-O-isopropylidene-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine (137655-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na, EtOH / Heating

2: 3 h / Heating

With ethanol; sodium;

DOI:10.1002/jhet.5570280529

upstream raw materials:

benzoic acid ethyl ester

4-(azidomethyl)-2,2?dimethyl-1,3-dioxolane

(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

solketal tosylate

Downstream raw materials:

(+/-)-3-2',3'-dihydroxypropyl-5-phenyl-7-hydroxy-3H-1,2,3-triazolo<4,5-d>pyrimidine

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