2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

Base Information

Chemical Name:2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide
CAS No.:1313512-98-9
Molecular Formula:C₄₉H₄₈ClNO₉
Molecular Weight:830.374
Hs Code.:

2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

Synonyms:2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

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Chemical Property of 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

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Technology Process of 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

There total 11 articles about 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1259020-54-6
2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)acetic acid

: 88352-86-7
(furan-2-ylcarbonyl)methylamine hydrochloride

: 1313512-98-9
2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.052

Reference yield:

: 1033723-31-7
(5-bromo-2-chloro-4-methoxyphenyl)methanol

: 1313512-98-9
2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

2.3: -50 - -10 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: pyridine; phosphorus tribromide / diethyl ether / 0 - 20 °C / Inert atmosphere; Reflux

5.1: 18-crown-6 ether / acetonitrile / 1 h / 85 °C / Inert atmosphere

6.1: sodium hydroxide / ethanol; water / 15 h / 100 °C / Inert atmosphere

6.2: 0 °C

7.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; 1H-imidazole; dmap; n-butyllithium; 18-crown-6 ether; tetrabutyl ammonium fluoride; phosphorus tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.052

Reference yield:

: 1259020-50-2
(5-bromo-2-chloro-4-methoxybenzyloxy)triisopropylsilane

: 1313512-98-9
2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

1.3: -50 - -10 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: pyridine; phosphorus tribromide / diethyl ether / 0 - 20 °C / Inert atmosphere; Reflux

4.1: 18-crown-6 ether / acetonitrile / 1 h / 85 °C / Inert atmosphere

5.1: sodium hydroxide / ethanol; water / 15 h / 100 °C / Inert atmosphere

5.2: 0 °C

6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; n-butyllithium; 18-crown-6 ether; tetrabutyl ammonium fluoride; phosphorus tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.052