3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

Base Information

Chemical Name:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide
CAS No.:1351087-86-9
Molecular Formula:C₁₆H₁₈BrN₇O₂S
Molecular Weight:452.335
Hs Code.:

Synonyms:3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

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Chemical Property of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

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Technology Process of 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

There total 6 articles about 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

: 1351087-86-9
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

Guidance literature:: With ammonium hydroxide; In methanol; chloroform;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351087-86-9
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: triethylamine / tetrahydrofuran / 1 h / -35 °C

3: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

4: acetic acid / 1,4-dioxane / 18 h / 100 °C / Sealed tube

5: ethanol / 2.33 h / 160 - 170 °C / Microwave irradiation

6: ammonium hydroxide / chloroform; methanol

With chlorosulfonic acid; hydrogen; ammonium hydroxide; acetic acid; triethylamine; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351087-86-9
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(1-pyrrolidinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

3: acetic acid / 1,4-dioxane / 18 h / 100 °C / Sealed tube

4: ethanol / 2.33 h / 160 - 170 °C / Microwave irradiation

5: ammonium hydroxide / chloroform; methanol

With hydrogen; ammonium hydroxide; acetic acid; triethylamine; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform;