1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester
• CAS No.: 858340-91-7
• Molecular Formula: C15H11 N3 O6 S
• Molecular Weight: 361.335
• Hs Code.: 2933990090
• Mol file: 858340-91-7.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester

Chemical Property:

• Vapor Pressure: 1.93E-13mmHg at 25°C
• Refractive Index: 1.686
• Boiling Point: 579.9°C at 760 mmHg
• Flash Point: 304.5°C
• PSA: 132.46000
• Density: 1.55g/cm³
• LogP: 3.57210
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 5-nitro-1-phenylsulfonyl-7-azaindole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester

There total 2 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester (245064-81-7) → methyl 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (858340-91-7)

Guidance literature:

With tetrabutylammonium nitrate; trifluoroacetic anhydride; In dichloromethane; at 4 ℃; for 27h;

Reference yield: 74.7%

trifluoroacetic anhydride (407-25-0) + 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester (245064-81-7) → methyl 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (858340-91-7)

Guidance literature:

trifluoroacetic anhydride; With tetrabutylammonium nitrate; In dichloromethane; at 0 ℃; for 0.416667h;

1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; In dichloromethane; at 4 ℃; for 27h;

Reference yield: 93.1%

methyl 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (858340-91-7) → disodium 5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

Guidance literature:

With sodium hydroxide; water; In 2,2,2-trifluoroethanol; at 0 ℃; for 18.6667h; Heating / reflux;

upstream raw materials:

1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

trifluoroacetic anhydride

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