1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one

Base Information

• Chemical Name: 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one
• CAS No.: 172295-15-7
• Molecular Formula: C₂₂H₃₃NOS₂Si
• Molecular Weight: 419.728
• Mol file: 172295-15-7.mol

Synonyms:1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one

Chemical Property of 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one

There total 2 articles about 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,2-bis(ethylthio)acetyl chloride (39098-91-4) + Benzyl-[3-triethylsilanyl-prop-2-yn-(E)-ylidene]-amine → 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one (172295-15-7)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jo9811219

Reference yield:

2,2-bis(ethylthio)acetyl chloride (39098-91-4) + 3-(triethylsilyl)-2-propynal N-benzylimine → 1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one (172295-15-7)

Guidance literature:

With n-butyllithium; triethylamine; Yield given. Multistep reaction; 1.) THF, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 15 min;

DOI:10.1021/jo00125a038

Reference yield: 92.0%

1-Benzyl-3,3-bis-ethylsulfanyl-4-triethylsilanylethynyl-azetidin-2-one (172295-15-7) → (1S,5S)-6-Benzyl-1-ethylsulfanyl-4-iodo-3-triethylsilanyl-2-thia-6-aza-bicyclo[3.2.0]hept-3-en-7-one

Guidance literature:

With iodine; In dichloromethane; Ambient temperature;

DOI:10.1021/jo00125a038 DOI:10.1021/jo9811219

upstream raw materials:

2,2-bis(ethylthio)acetyl chloride