(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

Base Information

Chemical Name:(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea
CAS No.:1260435-12-8
Molecular Formula:C₂₀H₂₇F₆N₃S
Molecular Weight:455.511
Hs Code.:

Synonyms:(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

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Chemical Property of (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

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Technology Process of (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

There total 5 articles about (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 338731-71-8
(S)-3,3-dimethyl-1-(piperidin-1-yl)butan-2-amine

: 1260435-12-8
(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

Guidance literature:: In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/chem.201002202

Reference yield:

: 20859-02-3
L-tert-Leucine

: 1260435-12-8
(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrahydrofuran; water / 12 h / 0 - 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 8.5 h / 0 - 20 °C

3: acetyl chloride / methanol / 8 h / 0 - 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5: dichloromethane / 3 h / 20 °C

With lithium aluminium tetrahydride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/acs.joc.5b01081

Reference yield:

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 1260435-12-8
(S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3,3-dimethyl-1-(piperidin-1-yl)butan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 8.5 h / 0 - 20 °C

2: acetyl chloride / methanol / 8 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4: dichloromethane / 3 h / 20 °C

With lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.joc.5b01081