5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole

Base Information

Chemical Name:5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole
CAS No.:180637-93-8
Molecular Formula:C₁₄H₁₅BrN₂O
Molecular Weight:307.19
Hs Code.:
DSSTox Substance ID:DTXSID301165925

Synonyms:5-BROMO-3-[(2R)-1-METHYLPYRROLIDINE-2-CARBONYL]-1H-INDOLE;180637-93-8;SCHEMBL13587694;DTXSID301165925;EN300-697480;Methanone, (5-bromo-1H-indol-3-yl)(1-methyl-2-pyrrolidinyl)-, (R)-

Suppliers and Price of 5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:306.03678
Heavy Atom Count:18
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CCCC1C(=O)C2=CNC3=C2C=C(C=C3)Br
Isomeric SMILES:CN1CCC[C@@H]1C(=O)C2=CNC3=C2C=C(C=C3)Br

Technology Process of 5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole

There total 2 articles about 5-Bromo-3-[(2R)-1-methylpyrrolidine-2-carbonyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-55-8
(R)-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole

: C₁₄H₁₇BrN₂O

: 180637-93-8
C₁₄H₁₅BrN₂O

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In tert-butyl methyl ether; toluene; at 30 - 48 ℃; for 3.16667h;

With sodium hydroxide; water; In tert-butyl methyl ether; toluene; at 15 - 20 ℃; for 0.5h; Product distribution / selectivity;

Reference yield: 57.0%

: 143322-56-9,331842-86-5
(R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole

: 143322-55-8
(R)-3-(1-methyl-2-pyrrolidinylmethyl)-1H-indole

: C₁₄H₁₇BrN₂O

: 180637-93-8
C₁₄H₁₅BrN₂O

: 100-51-6,185532-71-2
benzyl alcohol

: 143322-57-0,208464-41-9,312949-16-9
(R)-5-bromo-3-(N-methylpyrrolidine-2-ylmethyl)-1H-indole

Guidance literature:: (R)-3-[(N-benzyloxycarbonylpyrrolidin-2-yl)carbonyl]-5-bromo-1H-indole; With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 30 - 48 ℃; for 2.66667h;

With sodium hydroxide; water; In toluene; at 15 - 20 ℃; for 1h; Product distribution / selectivity;