5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

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Chemical Name:5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide
CAS No.:1617522-52-7
Molecular Formula:C₁₉H₂₀N₄O₃
Molecular Weight:352.393
Hs Code.:

Synonyms:5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of 5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

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Technology Process of 5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about 5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1990-90-5,953018-16-1
4-amino-3-methylpyridine

: 1177228-47-5
C₁₃H₁₄N₂O₄

: 1617522-52-7
5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 23 ℃; for 2h;

Reference yield:

: 1456071-47-8
C₁₄H₁₆N₂O₄

: 1617522-52-7
5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water / 1,4-dioxane / 1 h / 70 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 2 h / 23 °C

With water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 51985-95-6
methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

: 1617522-52-7
5-(2,5-dimethoxyphenyl)-1-methyl-N-(3-methyl-pyridin-4-yl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus(V) oxybromide / acetonitrile / 18 h / 80 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1.5 h / 100 °C / Microwave irradiation

3: lithium hydroxide; water / 1,4-dioxane / 1 h / 70 °C

4: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 2 h / 23 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; lithium hydroxide; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; 2: |Suzuki Coupling;