Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate

Base Information

• Chemical Name: Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate
• CAS No.: 330794-19-9
• Molecular Formula: C₂₈H₃₂N₆O₃
• Molecular Weight: 500.6

Synonyms:Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate

Chemical Property of Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate

Chemical Property:

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Technology Process of Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate

There total 2 articles about Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]-pyrimidin-4-amine (330785-90-5) + bromoacetic acid tert-butyl ester (5292-43-3) → Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate (330794-19-9)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3-(4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]-pyrimidin-4-amine (330785-90-5) + trans-N2-(4-{4-Amino-1-[4-(4-methylpiperazino)cyclohexyl]-1H-pyrazolo [3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)benzo[b]furan-2-carboxamide P + bromoacetic acid tert-butyl ester (5292-43-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate (330794-19-9)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane;

Reference yield:

Tert-butyl 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino } acetate (330794-19-9) → 2-{4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidino} acetic acid

Guidance literature:

In water; acetone;

upstream raw materials:

3-(4-phenoxyphenyl)-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d]-pyrimidin-4-amine

bromoacetic acid tert-butyl ester

N,N-dimethyl-formamide

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