1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole

Base Information

• Chemical Name: 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole
• CAS No.: 1236769-69-9
• Molecular Formula: C₁₉H₂₁N₃OSi
• Molecular Weight: 335.481
• Mol file: 1236769-69-9.mol

Synonyms:1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole

Chemical Property of 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole

There total 1 articles about 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol (153889-90-8,153889-99-7) → 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole (1236769-69-9)

Guidance literature:

With iron(III) chloride; In acetonitrile; at 90 ℃; for 5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol101082v

Reference yield: 96.0%

azidomethyl pivalate (872700-68-0) + 1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole (1236769-69-9) → (4-((1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methyl)-1H-1,2,3-triazol-1-yl)methyl pivalate (1236769-77-9)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h; regioselective reaction;

DOI:10.1021/ol101082v

Reference yield: 92.0%

1-(1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-1H-benzo[d][1,2,3]triazole (1236769-69-9) + benzyl azide (622-79-7) → 1-((1-benzyl-1H-1,2,3-triazol-4-yl)(2-methoxyphenyl)methyl)-1H-benzo[d][1,2,3]triazole (1236769-76-8)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 12h; regioselective reaction;

DOI:10.1021/ol101082v

upstream raw materials:

1,2,3-Benzotriazole

1-(2-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol

Downstream raw materials:

(4-((1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methyl)-1H-1,2,3-triazol-1-yl)methyl pivalate

1-((1-benzyl-1H-1,2,3-triazol-4-yl)(2-methoxyphenyl)methyl)-1H-benzo[d][1,2,3]triazole