2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine

Base Information

• Chemical Name: 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine
• CAS No.: 1392002-57-1
• Molecular Formula: C₂HF₃O₂*C₁₁H₁₅ClN₂
• Molecular Weight: 324.73
• Mol file: 1392002-57-1.mol

Synonyms:2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine

Chemical Property of 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine

There total 2 articles about 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-(2-chloro-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester (946399-73-1) + trifluoroacetic acid (76-05-1) → 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine (1392002-57-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

Reference yield:

2-iodochlorobenzene (615-41-8) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → 2,2,2-trifluoroacetic acid; N-(2-chlorophenyl)piperidin-4-amine (1392002-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 72 h / 100 °C

2: dichloromethane / 18 h / 20 °C

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-(2-chloro-phenylamino)-piperidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

2-iodochlorobenzene

1-(tert-butoxycarbonyl)-4-aminopiperidine