2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane

Base Information

Chemical Name:2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane
CAS No.:115115-25-8
Molecular Formula:C₂₅H₃₄O₃S₃
Molecular Weight:478.741
Hs Code.:

Synonyms:2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane

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Chemical Property of 2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane

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Technology Process of 2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane

There total 8 articles about 2-<(1S,2R,3S.4S)-1-hydroxy-4-methyl-3-(phenylsulfonyl)-2-cyclopentyl>-2-<(1R,6S)-7,7-dimethylbicyclo<4.1.0>hept-2-en-3-yl>-1,3-dithiacyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 78012-41-6
(1R,6S)-7,7-dimethyl-3-(1,3-dithia-2-cyclohexyl)bicyclo<4.1.0>hept-2-ene

: 78087-19-1
(1R,4R)-trans-4-methyl-3-(phenylsulfonyl)-2-cyclopenten-1-ol

: 78012-43-8,115115-25-8,115115-28-1
(1S,4S)-3-Benzenesulfonyl-2-[2-((1R,6S)-7,7-dimethyl-bicyclo[4.1.0]hept-2-en-3-yl)-[1,3]dithian-2-yl]-4-methyl-cyclopentanol

Guidance literature:: With n-butyllithium; methyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00398a050

Reference yield:

: 14917-83-0,247911-68-8
(1R,6S)-7,7-dimethylbicyclo[4.1.0]hept-2-ene-3-carboxaldehyde

: 78012-43-8,115115-25-8,115115-28-1
(1S,4S)-3-Benzenesulfonyl-2-[2-((1R,6S)-7,7-dimethyl-bicyclo[4.1.0]hept-2-en-3-yl)-[1,3]dithian-2-yl]-4-methyl-cyclopentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / boron trifluoride etherate / CH₂Cl₂

2: 65 percent / methyllithium, n-butyllithium / tetrahydrofuran / -78 °C

With n-butyllithium; boron trifluoride diethyl etherate; methyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00398a050

Reference yield:

: 18031-40-8
(S)-(-)-perillaldehyde

: 78012-43-8,115115-25-8,115115-28-1
(1S,4S)-3-Benzenesulfonyl-2-[2-((1R,6S)-7,7-dimethyl-bicyclo[4.1.0]hept-2-en-3-yl)-[1,3]dithian-2-yl]-4-methyl-cyclopentanol

Guidance literature:: Multi-step reaction with 4 steps

1: HCl gas / liquid sulphur dioxide / 0.33 h / -45 °C

2: 94 percent / potassium tert-butoxide / tetrahydrofuran / 0 °C

3: 68 percent / boron trifluoride etherate / CH₂Cl₂

4: 65 percent / methyllithium, n-butyllithium / tetrahydrofuran / -78 °C

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; methyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00398a050