N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

Base Information

Chemical Name:N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide
CAS No.:937701-86-5
Molecular Formula:C₂₈H₃₄N₄O₅
Molecular Weight:506.602
Hs Code.:

Synonyms:N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

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Chemical Property of N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

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Technology Process of N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

There total 4 articles about N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 927998-99-0
4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenylamine

: 5653-40-7
2-Amino-4,5-dimethoxybenzoic acid

: 937701-86-5
N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

Guidance literature:: With benzotriazol-1-ol; methyl p-toluene sulfonate; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2007.03.014

Reference yield:

: 414877-58-0
1-(3,4-dimethoxybenzyl)-4-(4-nitrophenyl)piperazine

: 937701-86-5
N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / hydrogen / Pd/C / ethanol / 6 h / 1965.21 Torr

2: 70 percent / N-cyclohexyl-N-(2-morpholinoethyl)-carbodiimide; methyl p-toluenesulfonate; 1-hydroxybenzotriazole / CH₂Cl₂ / 48 h / 20 °C

With hydrogen; benzotriazol-1-ol; methyl p-toluene sulfonate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2007.03.014

Reference yield:

: 6269-89-2
1-(4-Nitrophenyl)piperazine

: 937701-86-5
N-(4-(4-(3,4-dimethoxybenzyl)-piperazin-1-yl)phenyl)-2-amino-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 18 h

2: 100 percent / hydrogen / Pd/C / ethanol / 6 h / 1965.21 Torr

3: 70 percent / N-cyclohexyl-N-(2-morpholinoethyl)-carbodiimide; methyl p-toluenesulfonate; 1-hydroxybenzotriazole / CH₂Cl₂ / 48 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; methyl p-toluene sulfonate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2007.03.014