2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

Base Information

Chemical Name:2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide
CAS No.:1427158-60-8
Molecular Formula:C₂₆H₂₁ClF₃N₅O₂S
Molecular Weight:559.999
Hs Code.:

Synonyms:2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

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Chemical Property of 2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

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Technology Process of 2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

There total 20 articles about 2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427158-09-5
N³-[4-(trifluoromethyl)phenyl][1,2]thiazolo[4,5-b]pyridine-3,7-diamine

: C₁₈H₂₂ClNO₅

: 1427158-60-8
2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 22 - 26 ℃;

Reference yield:

: 1427158-10-8
3-bromo-4-chloropyridine-2-carbonitrile

: 1427158-60-8
2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 70 °C

2: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

3: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

5: trifluoroacetic acid / 2 h / 80 °C

6: sodium hydride / tetrahydrofuran; mineral oil / 22 - 26 °C

With 1-methyl-pyrrolidin-2-one; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium thiomethoxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1427158-11-9
3-bromo-4-[(4-methoxybenzyl)amino]pyridine-2-carbonitrile

: 1427158-60-8
2-chloro-5-((1-methylcyclopropanecarboxamido)methyl)-N-(3-((4-(trifluoromethyl)phenyl)amino)isothiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

2: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

4: trifluoroacetic acid / 2 h / 80 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 22 - 26 °C

With 1-methyl-pyrrolidin-2-one; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium thiomethoxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; mineral oil;