C₁₆H₂₂O₄

Base Information

• Chemical Name: C₁₆H₂₂O₄
• CAS No.: 1318263-37-4
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 1318263-37-4.mol

Synonyms:C₁₆H₂₂O₄

Chemical Property of C₁₆H₂₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂O₄

There total 2 articles about C₁₆H₂₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H16O4 (1318263-33-0) + isopropyl alcohol (67-63-0,8013-70-5) → C16H22O4 (1318263-37-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol201795w

Reference yield:

(E)-4-(benzyloxy)-2-buten-1-ol (80885-30-9,81028-03-7,69152-88-1) → C16H22O4 (1318263-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,2-dichloro-ethane; 2.1: Steglich esterification;

DOI:10.1021/ol201795w

Reference yield: 89.0%

C16H22O4 (1318263-37-4) + acetaldehyde (75-07-0,9002-91-9) → C18H26O5 (1318263-40-9)

Guidance literature:

C₁₆H₂₂O₄; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

acetaldehyde; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol201795w

upstream raw materials:

C₁₃H₁₆O₄

isopropyl alcohol

(E)-4-(benzyloxy)-2-buten-1-ol

Downstream raw materials:

C₁₈H₂₄O₄

C₁₈H₂₆O₅