trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one

Base Information

• Chemical Name: trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one
• CAS No.: 123003-79-2
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Mol file: 123003-79-2.mol

Synonyms:trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one

Chemical Property of trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one

There total 17 articles about trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid (124156-28-1) + lead(IV) tetraacetate (546-67-8) → trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one (123003-79-2) + cis-4-acetoxy-1-p-anisyl-3-isopropylazetidin-2-one

Guidance literature:

With copper diacetate; In acetonitrile; at 80 ℃; for 1.5h; Yields of byproduct given;

DOI:10.1021/jo00048a027

Reference yield: 74.0%

cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid (124156-28-1) + lead(IV) tetraacetate (546-67-8) → 1-p-anisyl-3-isopropyl-4-acetoxy-2-azetidinone (123003-79-2,124156-29-2,124156-39-4,143902-59-4)

Guidance literature:

With acetic acid; In N,N-dimethyl-formamide; at 60 ℃; for 0.0833333h;

DOI:10.1021/jo00289a035

Reference yield: 46.0%

trans-4-acetyl-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one (123003-78-1) → trans-4-acetoxy-3-isopropyl-1-(4-methoxyphenyl)azetidin-2-one (123003-79-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In benzene; for 5h; Heating;

DOI:10.1021/jo00285a021

upstream raw materials:

cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid

lead(IV) tetraacetate

3,3-Dimethylacryloyl chloride

ethyl (4-methoxyphenylimino)acetate

Downstream raw materials:

3-isopropyl-4-acetoxy-2-azetidinone

trans-4-acetoxy-3-isopropylazetidin-2-one