2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

Base Information

Chemical Name:2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene
CAS No.:1621100-85-3
Molecular Formula:C₁₉H₁₃F₃N₂O₄
Molecular Weight:390.318
Hs Code.:

Synonyms:2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

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Technology Process of 2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

There total 4 articles about 2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 157224-25-4
1,3-difluoro-5-(2-nitrovinyl)-benzene

: 1621100-74-0
2-(fluoro(nitro)methyl)naphthalene

: 1621100-85-3
2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

: 2-(2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

Guidance literature:: With C₄₈H₅₃F₆N₅O₂SSi; In toluene; at 0 ℃; for 48h; diastereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/c4cc03513e

Reference yield:

: 939-26-4
2-bromomethylnaphthyl bromide

: 1621100-85-3
2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

: 2-(2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: sodium nitrite; urea / N,N-dimethyl-formamide / -20 °C

2: Selectfluor / acetonitrile; water / 12 h / 20 °C

3: C₄₈H₅₃F₆N₅O₂SSi / toluene / 48 h / 0 °C / Inert atmosphere; Sealed tube

With C₄₈H₅₃F₆N₅O₂SSi; Selectfluor; urea; sodium nitrite; In water; N,N-dimethyl-formamide; toluene; acetonitrile; 3: |Michael Addition;
DOI:10.1039/c4cc03513e

Reference yield:

: 4382-19-8
2-(nitromethyl)naphthalene

: 1621100-85-3
2-((1S,2S)-2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

: 2-(2-(3,5-difluorophenyl)-1-fluoro-1,3-dinitropropyl)naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile; water / 12 h / 20 °C

2: C₄₈H₅₃F₆N₅O₂SSi / toluene / 48 h / 0 °C / Inert atmosphere; Sealed tube

With C₄₈H₅₃F₆N₅O₂SSi; Selectfluor; In water; toluene; acetonitrile; 2: |Michael Addition;
DOI:10.1039/c4cc03513e