Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

Base Information

Chemical Name:Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn
CAS No.:253790-50-0
Molecular Formula:C₄₈H₇₀N₆O₉
Molecular Weight:875.119
Hs Code.:

Boc-(S)-β<sup>3</sup>-HPro-(S)-β<sup>3</sup>-HPro-(S)-β<sup>3</sup>-HPro-(S)-β<sup>3</sup>-HPro-(S)-β<sup>3</sup>-HPro-(S)-β<sup>3</sup>-HPro-OBn

Synonyms:Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

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Chemical Property of Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

Chemical Property:

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Technology Process of Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

There total 8 articles about Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 253790-46-4
Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OH

: TFA*H-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

: 253790-50-0
Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In chloroform; at 0 - 20 ℃; for 60h;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1539::AID-HLCA1539>3.0.CO;2-E

Reference yield:

: 253790-45-3
Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

: 253790-50-0
Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 18 h

2: 85 percent / Et₃N; HOBt; EDC / CHCl₃ / 60 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In chloroform; ethyl acetate; 1: Hydrogenolysis / 2: Substitution;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1539::AID-HLCA1539>3.0.CO;2-E

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 253790-50-0
Boc-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-(S)-β³-HPro-OBn

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent

2: 61 percent / CF₃COOAg; H₂O / tetrahydrofuran

3: 91 percent / Et₃N; HOBt; EDC / CHCl₃ / 16 h / 0 - 20 °C

4: 100 percent / hydrogen / 10 percent Pd/C / ethyl acetate / 18 h

5: 85 percent / Et₃N; HOBt; EDC / CHCl₃ / 60 h / 0 - 20 °C

With water; hydrogen; silver trifluoroacetate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate; 1: Diazotization / 2: Rearrangement / 3: Substitution / 4: Hydrogenolysis / 5: Substitution;
DOI:10.1002/(SICI)1522-2675(19991006)82:10<1539::AID-HLCA1539>3.0.CO;2-E