N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

Base Information

Chemical Name:N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide
CAS No.:857636-32-9
Molecular Formula:C₂₂H₂₄N₂O₃
Molecular Weight:364.444
Hs Code.:

Synonyms:N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

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Chemical Property of N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

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Technology Process of N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

There total 3 articles about N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2904-57-6
mesitylenecarbonitrile oxide

: 613672-33-6
(E)-N-(2-methylbut-2-enoyl)benzamide

: N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

: 857636-32-9
N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

Guidance literature:: With magnesium(II) perchlorate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In dichloromethane; at 20 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1021/ol050599d

Reference yield:

: 80-59-1
Tiglic acid

: 857636-32-9
N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 2.17 h / 0 - 20 °C

2.1: NaH / tetrahydrofuran / 0.92 h / 0 - 20 °C

2.2: tetrahydrofuran / 4.17 h / 0 - 20 °C

3.1: Ni(ClO₄)2; 1,1-bis[(R,S)-3aH,8bH-indeno[3,2-d]oxazol-2-yl]-c-propane / CH₂Cl₂ / 96 h / 20 °C

With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); oxalyl dichloride; sodium hydride; nickel(II) perchlorate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol050599d

Reference yield:

: 35660-94-7
(E)-2-methylbut-2-enoyl chloride

: 857636-32-9
N-[4,5-dihydro-3-(2,4,6-trimethylphenyl)-4,5-dimethylisoxazol-5-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.92 h / 0 - 20 °C

1.2: tetrahydrofuran / 4.17 h / 0 - 20 °C

2.1: Ni(ClO₄)2; 1,1-bis[(R,S)-3aH,8bH-indeno[3,2-d]oxazol-2-yl]-c-propane / CH₂Cl₂ / 96 h / 20 °C

With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); sodium hydride; nickel(II) perchlorate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol050599d