(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

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Chemical Name:(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol
CAS No.:283597-76-2
Molecular Formula:C₄₆H₄₄N₂O₂
Molecular Weight:656.868
Hs Code.:

(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

Synonyms:(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

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Chemical Property of (1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

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Technology Process of (1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

There total 8 articles about (1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 283597-81-9
(1R,2S)-2-({4-[3-(4-{[((1S,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-5-trimethylsilanylethynyl-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

: 283597-76-2
(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)00365-8

Reference yield:

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 283597-76-2
(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: Pd(PPh₃)4; CuI; Et₃N / toluene / Heating

2: LiAlH₄ / diethyl ether

3: Bu₄NF / tetrahydrofuran

4: Et₃N / CH₂Cl₂

5: K₂CO₃ / acetonitrile / Heating

6: 49 percent / Pd(PPh₃)4; CuI; Et₃N / tetrahydrofuran / Heating

7: 69 percent / Pd(PPh₃)4; CuI; Et₃N / dimethylformamide

8: 83 percent / Bu₄NF / tetrahydrofuran

With copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 1: Alkylation / 2: Reduction / 3: deprotection / 4: mesylation / 5: Condensation / 6: Condensation / 7: Condensation / 8: deprotection;
DOI:10.1016/S0040-4039(00)00365-8

Reference yield:

: 10602-04-7
(4-ethynylphenyl)methanol

: 283597-76-2
(1R,2S)-2-({4-[3-Ethynyl-5-(4-{[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-methyl}-phenylethynyl)-phenylethynyl]-benzyl}-methyl-amino)-1-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: K₂CO₃ / acetonitrile / Heating

3: 49 percent / Pd(PPh₃)4; CuI; Et₃N / tetrahydrofuran / Heating

4: 69 percent / Pd(PPh₃)4; CuI; Et₃N / dimethylformamide

5: 83 percent / Bu₄NF / tetrahydrofuran

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: mesylation / 2: Condensation / 3: Condensation / 4: Condensation / 5: deprotection;
DOI:10.1016/S0040-4039(00)00365-8