({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

Base Information

Chemical Name:({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester
CAS No.:1026410-46-7
Molecular Formula:C₂₈H₂₇N₆O₃P
Molecular Weight:526.535
Hs Code.:

Synonyms:({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

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Chemical Property of ({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

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Technology Process of ({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

There total 3 articles about ({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102-10-3
diphenyl phosphite

: 3-{5-[1-(Hydroxymethyl-amino)-4-p-tolyl-but-3-ynyl]-tetrazol-1-yl}-propionitrile

: 1026410-46-7
({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

Guidance literature:: With phenol; In tetrahydrofuran; toluene; at 65 ℃; for 1.5h;
DOI:10.1021/jm970787c

Reference yield:

: 3-[5-(1-Amino-4-p-tolyl-but-3-ynyl)-tetrazol-1-yl]-propionitrile

: 1026410-46-7
({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate; H₂O / 16 h / Ambient temperature

2: PhOH / toluene; tetrahydrofuran / 1.5 h / 65 °C

With phenol; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/jm970787c

Reference yield:

: 1026354-56-2
{1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynyl}-carbamic acid tert-butyl ester

: 1026410-46-7
({1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-p-tolyl-but-3-ynylamino}-methyl)-phosphonic acid diphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HCO₂H / 5 h / 40 °C

2: ethyl acetate; H₂O / 16 h / Ambient temperature

3: PhOH / toluene; tetrahydrofuran / 1.5 h / 65 °C

With formic acid; phenol; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/jm970787c