(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester
CAS No.:83314-89-0
Molecular Formula:C₂₄H₃₀N₈O₅
Molecular Weight:510.553
Hs Code.:

Synonyms:(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

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Technology Process of (S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

There total 3 articles about (S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 52853-40-4
6-bromomethyl-2,4-diaminopteridine hydrobromide

: 83314-86-7
diethyl N-(p-aminobenzyl)-N-formyl-L-glutamate

: 83314-89-0
(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; for 168h; Ambient temperature;
DOI:10.1021/jm00354a013

Reference yield:

: 83334-49-0
diethyl N-formyl-N-(p-nitrobenzyl)-L-glutamate

: 83314-89-0
(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / H₂ / 5percent Pd/C / ethanol

2: 59 percent / K₂CO₃ / N,N-dimethyl-acetamide / 168 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00354a013

Reference yield:

: 83314-84-5
diethyl N-(p-nitrobenzyl)-L-glutamate hydrochloride salt

: 83314-89-0
(S)-2-({4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzyl}-formyl-amino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / N,N'-dicyclohexylcarbodiimide, Et₃N, pyridine / CHCl₃

2: 78 percent / H₂ / 5percent Pd/C / ethanol

3: 59 percent / K₂CO₃ / N,N-dimethyl-acetamide / 168 h / Ambient temperature

With pyridine; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl acetamide;
DOI:10.1021/jm00354a013