1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan

Base Information

• Chemical Name: 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan
• CAS No.: 124840-71-7
• Molecular Formula: C₁₇H₁₈BrNO₄
• Molecular Weight: 380.238
• Mol file: 124840-71-7.mol

Synonyms:1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan

Chemical Property of 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan

There total 3 articles about 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(5-Brom-4-O-ethoxycarbonyl-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan → 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan (124840-71-7)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 7h; Ambient temperature;

DOI:10.1002/ardp.19893220805

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan (124840-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.5 percent / pyridine / CHCl₃ / 0.5 h / 90 °C

2: 79 percent / 1N aq. NaOH / dioxane / 7 h / Ambient temperature

With pyridine; sodium hydroxide; In 1,4-dioxane; chloroform;

DOI:10.1002/ardp.19893220805

Reference yield:

1-(5-Brom-4-O-ethoxycarbonyl-3-methoxy-phenyl)-2-aminoethan-hydrochlorid → 1-(5-Brom-4-hydroxy-3-methoxy-phenyl)-2-(N-benzyloxycarbonyl)-ethan (124840-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.5 percent / pyridine / CHCl₃ / 0.5 h / 90 °C

2: 79 percent / 1N aq. NaOH / dioxane / 7 h / Ambient temperature

With pyridine; sodium hydroxide; In 1,4-dioxane; chloroform;

DOI:10.1002/ardp.19893220805

upstream raw materials:

benzyl chloroformate