5-(tert-butoxycarbonylaMino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid

Base Information

• Chemical Name: 5-(tert-butoxycarbonylaMino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid
• CAS No.: 1270034-25-7
• Molecular Formula: C₁₅H₁₄F₂N₂O₄S
• Molecular Weight: 356.35
• Mol file: 1270034-25-7.mol

Synonyms:5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid

Chemical Property of 5-(tert-butoxycarbonylaMino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid

Chemical Property:

• PKA: 2.76±0.36(Predicted)
• Density: 1.440±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

5-(tert-Butoxycarbonylamino)-2-(2,6-difluorophenyl)-thiazole-4-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

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Technology Process of 5-(tert-butoxycarbonylaMino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid

There total 6 articles about 5-(tert-butoxycarbonylaMino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylate (1620011-01-9) → 5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid (1270034-25-7)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 60 ℃; for 5h;

Reference yield: 96.0%

ethyl 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylate → 5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid (1270034-25-7)

Guidance literature:

With lithium hydroxide monohydrate; water; In methanol; at 50 ℃; for 14h;

DOI:10.1021/acs.jmedchem.8b01857

Reference yield: 25.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl 5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxylate (1187056-41-2) → 5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid (1270034-25-7)

Guidance literature:

di-tert-butyl dicarbonate; ethyl 5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxylate; With dmap; In dichloromethane; for 1h;

With water; lithium hydroxide; In tetrahydrofuran; at 55 ℃; for 48h;

upstream raw materials:

N-(1-cyano-2-ethylperoxyethyl)-2,6-difluorobenzamide

di-tert-butyl dicarbonate

ethyl 5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxylate

methyl 2-bromo-5-[(tert-butoxycarbonyl)amino]-1,3-thiazole-4-carboxylate

Downstream raw materials:

tert-butyl 4-(5-(4,4-difluoro-5-(2,2,2-trifluoroacetamido)azepan-1-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

tert-butyl 2-(2,6-difluorophenyl)-4-(1-ethyl-5-(4-(2,2,2-trifluoroacetamido)azepan-1-yl)-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate

R-5-amino-N-(5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide

(R)-N-(5-(4-acetamidoazepan-1-yl)-1-methyl-1H-pyrazol-4-yl)-5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxamide

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