Thiophene, 3-acetamido-5-ethyl-2-methyl- (5CI)

Base Information

• Chemical Name: Thiophene, 3-acetamido-5-ethyl-2-methyl- (5CI)
• CAS No.: 857359-97-8
• Molecular Formula: C₉H₁₃NOS
• Molecular Weight: 183.274
• Mol file: 857359-97-8.mol

Synonyms:Thiophene,3-acetamido-5-ethyl-2-methyl- (5CI)

Chemical Property of Thiophene, 3-acetamido-5-ethyl-2-methyl- (5CI)

Chemical Property:

• PSA: 57.34000
• LogP: 2.65030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophene, 3-acetamido-5-ethyl-2-methyl- (5CI)

There total 3 articles about Thiophene, 3-acetamido-5-ethyl-2-methyl- (5CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-methyl-4-nitro-[2]thienyl)-ethanone (408507-64-2) → N-(5-ethyl-2-methyl-[3]thienyl)-acetamide (857359-97-8)

Guidance literature:

With cobalt polysulfide; acetic acid; at 200 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1021/ja01155a071

Reference yield:

2-Acetyl-5-methylthiophen (13679-74-8) → N-(5-ethyl-2-methyl-[3]thienyl)-acetamide (857359-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; nitric acid

2: cobalt polysulfide; acetic acid / 200 °C / 73550.8 Torr / Hydrogenation

With cobalt polysulfide; nitric acid; acetic acid;

DOI:10.1021/ja01155a071

Reference yield:

1-(4-acetylamino-5-methyl-[2]thienyl)-ethanone (408507-71-1) → N-(5-ethyl-2-methyl-[3]thienyl)-acetamide (857359-97-8)

Guidance literature:

With hydrogenchloride; amalgamated zinc; Behandeln des vom Zink befreiten, mit wss. Natronlauge neutralisierten Reaktionsgemisches mit Acetanhydrid;

DOI:10.1021/ja01155a071

upstream raw materials:

1-(5-methyl-4-nitro-[2]thienyl)-ethanone

1-(4-acetylamino-5-methyl-[2]thienyl)-ethanone

2-Acetyl-5-methylthiophen