4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

Base Information

Chemical Name:4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide
CAS No.:194085-52-4
Molecular Formula:C₁₇H₁₇NO₄S₂
Molecular Weight:363.458
Hs Code.:

Synonyms:4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

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Chemical Property of 4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

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Technology Process of 4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

There total 3 articles about 4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98-59-9
p-toluenesulfonyl chloride

: 194085-45-5
3,3a,4,8b-Tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

: 194085-52-4
4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(97)01183-0

Reference yield:

: 615-43-0
2-iodophenylamine

: 194085-52-4
4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / methanol / 84 h / Heating

2: 80 percent / Bu₃SnH, AIBN / benzene; methanol / 2 h / Heating

3: 89 percent / Et₃N / CH₂Cl₂ / 45 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In methanol; dichloromethane; benzene;
DOI:10.1021/jo980044e

Reference yield:

: 194085-44-4
(1,1-Dioxo-2,3-dihydro-1H-1λ⁶-thiophen-3-yl)-(2-iodo-phenyl)-amine

: 194085-52-4
4-(Toluene-4-sulfonyl)-3,3a,4,8b-tetrahydro-1H-thieno[3,4-b]indole 2,2-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Bu₃SnH, AIBN / benzene; methanol / 2 h / Heating

2: 89 percent / Et₃N / CH₂Cl₂ / 45 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In methanol; dichloromethane; benzene;
DOI:10.1021/jo980044e