6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

Base Information

Chemical Name:6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid
CAS No.:1035217-08-3
Molecular Formula:C₁₈H₂₆FN₃O₃
Molecular Weight:351.421
Hs Code.:

Synonyms:6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

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Chemical Property of 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

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Technology Process of 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

There total 1 articles about 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035217-06-1
ethyl 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinate

: 1035217-08-3
6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

Guidance literature:: ethyl 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 - 50 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; pH=2;

Reference yield:

: 1035217-08-3
6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid

: 1035217-10-7
N₁-(cyclohexylmethyl)-N₂-[3-fluoro-5-(hydroxymethyl)pyridin-2-yl]-D-valinamide

Guidance literature:: 6-({(1R)-1-[(cyclohexylmethyl)carbamoyl]-2-methylpropyl}amino)-5-fluoronicotinic acid; With 4-methyl-morpholine; isobutyl chloroformate; In 1,2-dimethoxyethane; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In 1,2-dimethoxyethane; water; at 0 - 20 ℃; for 1h;

With hydrogenchloride; water; pH=2;