N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester

Base Information

• Chemical Name: N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester
• CAS No.: 133703-69-2
• Molecular Formula: C₂₂H₂₇N₃O₅
• Molecular Weight: 413.473
• Mol file: 133703-69-2.mol

Synonyms:N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester

Chemical Property of N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester

There total 3 articles about N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester (84890-97-1) + 1,2-diamino-benzene (95-54-5) → N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester (133703-69-2)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm020336e

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester (133703-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NMM / dimethylformamide / -20 °C

2: dimethylformamide / 20 °C

3: 1.62 g / glacial AcOH / 65 °C

With 4-methyl-morpholine; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm020336e

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) + 1,2-diamino-benzene (95-54-5) → N-(2-amino-phenyl)-3-tert-butoxycarbonylamino-succinamic acid benzyl ester (133703-69-2)

Guidance literature:

BOC-L-aspartic acid 4-benzyl ester; With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 0.166667h;

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In toluene; at 20 ℃; for 0.166667h;

1,2-diamino-benzene; In toluene; at 20 ℃; for 4h;

DOI:10.1039/C8RA07773H

upstream raw materials:

(S)-3-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester

1,2-diamino-benzene

BOC-L-aspartic acid 4-benzyl ester

Downstream raw materials:

3-(1H-benzimidazol-2-yl)-3-tert-butoxycarbonylaminopropionic acid benzyl ester