2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene

Base Information

• Chemical Name: 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene
• CAS No.: 213613-18-4
• Molecular Formula: C₁₆H₂₄I₂O₂
• Molecular Weight: 502.174
• Mol file: 213613-18-4.mol

Synonyms:2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene

Chemical Property of 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene

There total 6 articles about 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic acid 5-[4-(5-acetoxy-pentyl)-2,5-diiodo-phenyl]-pentyl ester (213613-17-3) → 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene (213613-18-4)

Guidance literature:

With methanol; potassium carbonate;

DOI:10.1021/ja984138h

Reference yield:

para-dichlorobenzene (106-46-7,84348-21-0) → 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene (213613-18-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Mg / diethyl ether / Heating

1.2: 38 percent / dichloro[1,3-bis(diphenylphosphino)propane]nickel / diethyl ether / Heating

2.1: BH₃*THF / tetrahydrofuran / 3 h / 50 °C

2.2: 97 percent / NaOH; H₂O₂ / H₂O; tetrahydrofuran / 20 °C

3.1: 100 percent / pyridine / 20 °C

4.1: 92 percent / I₂; H₅IO₆ / acetic acid; aq. H₂SO₄ / 3 h / 80 °C

5.1: 95 percent / K₂CO₃ / methanol; CH₂Cl₂ / 20 °C

With pyridine; borane-THF; iodine; potassium carbonate; magnesium; periodic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; sulfuric acid; acetic acid; 1.1: Metallation / 1.2: cross-coupling / 2.1: hydroboration / 2.2: Oxidation / 3.1: Acetylation / 4.1: Iodination / 5.1: Hydrolysis;

DOI:10.1021/jo991201s

Reference yield:

1,4-di(5'-acetoxypentyl)benzene (213613-16-2) → 2,5-di(5'-hydroxypentyl)-1,4-diiodobenzene (213613-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / I₂; H₅IO₆ / acetic acid; aq. H₂SO₄ / 3 h / 80 °C

2: 95 percent / K₂CO₃ / methanol; CH₂Cl₂ / 20 °C

With iodine; potassium carbonate; periodic acid; In methanol; dichloromethane; sulfuric acid; acetic acid; 1: Iodination / 2: Hydrolysis;

DOI:10.1021/jo991201s

upstream raw materials:

acetic acid 5-[4-(5-acetoxy-pentyl)-2,5-diiodo-phenyl]-pentyl ester

para-dichlorobenzene

1,4-di(5'-hydroxy) pentyl benzene

1,4-di(5'-acetoxypentyl)benzene