2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

Base Information

Chemical Name:2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide
CAS No.:1308761-00-3
Molecular Formula:C₂₇H₂₃N₅O₂
Molecular Weight:449.512
Hs Code.:

Synonyms:2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

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Chemical Property of 2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

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Technology Process of 2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

There total 2 articles about 2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-methoxy-6-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

: 587-65-5
N-chloroacetyl-aniline

: 1308761-00-3
2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

: 1308760-92-0
2-(4-(4-methoxyquinolin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

Guidance literature:: With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2011.03.008

Reference yield:

: 6940-57-4
2-acetyl-6-methylpyridine

: 1308761-00-3
2-(4-(4-methoxyquinolin-6-yl-)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

: 1308760-92-0
2-(4-(4-methoxyquinolin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl)-N-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; palladium diacetate; DavePhos / tetrahydrofuran / 14 h / 75 °C

2.1: 4 h / 90 °C

2.2: 4 h / Reflux

3.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

With potassium tert-butylate; palladium diacetate; sodium hydride; sodium iodide; DavePhos; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.008