2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

Base Information

Chemical Name:2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester
CAS No.:875668-24-9
Molecular Formula:C₄₄H₆₁N₂O₁₇P
Molecular Weight:920.945
Hs Code.:

2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

Synonyms:2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

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Chemical Property of 2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

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Technology Process of 2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

There total 9 articles about 2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5621-44-3
dimethyl 2-methylenepentanedioate

: 875668-24-9
2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / aq. NaOH / methanol / 2 h / Heating

2: 42 percent / Ag₂CO₃; dimethyl methylphosphonate / dimethylformamide / 12 h / 20 °C

3: BSA / CH₂Cl₂ / Heating

With benzenesulfonamide; sodium hydroxide; silver carbonate; dimethyl methane phosphonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050871p

Reference yield:

: 875668-08-9
methyl (2S)-4-bromo-2-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]aminobutyrate

: 875668-24-9
2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaBH₄ / ethanol

1.2: 90 percent / ethanol / 0.5 h

2.1: aq. LiOH / methanol; CH₂Cl₂ / 2 h / 20 °C

3.1: 276 mg / dimethyl methylphosphonate; Ag₂CO₃ / dimethylformamide / 20 °C

4.1: 90 percent / aq. H₂O₂ / tetrahydrofuran / 1 h / Heating

5.1: ammonium hypophosphite; Et₃B / methanol; hexane / 3 h / 20 °C

6.1: BSA / CH₂Cl₂ / Heating

With benzenesulfonamide; lithium hydroxide; sodium tetrahydroborate; ammonium hypophosphite; triethyl borane; dihydrogen peroxide; silver carbonate; dimethyl methane phosphonate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050871p

Reference yield:

: 875668-19-2
methyl (2S)-2-N-[4-(N-carbobenzyloxy-N-methyl)aminobenzoyl]amino-4-(phenylselenyl)butyrate

: 875668-24-9
2-{[(S)-3-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-3-(2,2-dimethyl-propionyloxymethoxycarbonyl)-propyl]-hydroxy-phosphinoylmethyl}-pentanedioic acid bis-(2,2-dimethyl-propionyloxymethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. LiOH / methanol; CH₂Cl₂ / 2 h / 20 °C

2: 276 mg / dimethyl methylphosphonate; Ag₂CO₃ / dimethylformamide / 20 °C

3: 90 percent / aq. H₂O₂ / tetrahydrofuran / 1 h / Heating

4: ammonium hypophosphite; Et₃B / methanol; hexane / 3 h / 20 °C

5: BSA / CH₂Cl₂ / Heating

With benzenesulfonamide; lithium hydroxide; ammonium hypophosphite; triethyl borane; dihydrogen peroxide; silver carbonate; dimethyl methane phosphonate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050871p